Effect was quite immediately noticeable at the lowest dose and there was no need to go above 100mcl. Doses were gradually increased in 20mcl increments until an effect (see subjective description below) was felt, to ensure extraction was performed reasonably. A P20 pipette (which measures up to 20mcl) was used to evaluate the first doses. This would represent ~1mcg of fentanyl for 1mcl of H2O. (This is the main deviation from the OP no alcohol is used which leads to nearzero irritation of the nasal passage.). 4ml of sterile water was added to this residue and thoroughly mixed with the tip of the measuring syringe. The patches and adhesive are removed from solution towards the very end when about 1ml of IPA is left and the solution is allowed to dry completely. Halfway through the process (during the first readdition of IPA), the now white looking adhesive is easily rolled up and removed with a fingernail from the patch and both the rolled up adhesive and patch are put back in the solution. It takes about 30-45m for 50ml of IPA to evaporate in the ceramic bowl which gives an idea of the amount of heat applied. Another ~50ml of IPA was then added (2 IPA additions total, but more could be can be used depending on one's patience). The patches are immersed in 70% IPA (~50ml) and then stirred routinely until ~75% of solution was evaporated. A ceramic bowl with a hot pot can be used to create a water bath, with the patch(es) and solution in the ceramic bowl, and water in the hot pot surrounding it, and gentle heat is applied. So if a 25mcg/h patch contains 4.2ml total fentanyl, and a 12.5mcg/h patch contains 2.1ml of total fentanyl, and they were used for 67 hours, then this would be 6300 - (37.5*67) = 3787mcg, or ~3.8ml, of fentanyl. The total amount of fentanyl originally in the patch minus the number of hours used times the patch dosing is used for this calculation. The more information available on the length of use of a given patch, the better. If used patches are being reused, the remaining fentanyl is calculated as accurately as possible. Some additional detail is added (for example, the colouration of the adhesive) in the interests of harm reduction. The suggested way avoids alcohol in the end product which is a good thing IMO, is useable in a discreet manner. Deviations will require commensurate modifications.Ī way is suggested of extracting fentanyl from patch for intranasal and/or oral use which is working with slight deviations from Oxymorphone's protocol. The below procotol is suggested when one has achieved a steady state with 37.5mcg/h fentanyl transdermal patches. Fentanyl 75 mcg / Hour Transdermal Patch Pouch 5 Patches CII Mylan Pharmaceuticals 8.Comments and suggestions on this would be greatly appreciated! Not recommended for opiod/fentanyl naive people. Previous case reports have documented deaths afte. Unfortunately, the potential for their abuse is well recognized. Transdermal fentanyl patches are now widely utilized as an acceptable and efficacious method of medication delivery. Plugging Fentanyl Patch Mylan Treatment Plugging Fentanyl Patch Mylan Patchįentanyl is a potent opioid analgesic used in the treatment of pain. If you think you may have a medical emergency, call your physician or 911 immediately. By using this Site you agree to the following. We offer this Site AS IS and without any warranties. Never disregard the medical advice of your physician or health professional, or delay in seeking such advice, because of something you read on this Site.
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